MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication

Recently, MGME1 was identified as a mitochondrial DNA nuclease with preference for single-stranded DNA (ssDNA) substrates. Loss-of-function mutations in patients lead to mitochondrial disease with DNA depletion, deletions, duplications and rearrangements. Here, we assess the biochemical role of MGME...

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Detalles Bibliográficos
Autores principales: Uhler, Jay P., Thörn, Christian, Nicholls, Thomas J., Matic, Stanka, Milenkovic, Dusanka, Gustafsson, Claes M., Falkenberg, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937333/
https://www.ncbi.nlm.nih.gov/pubmed/27220468
http://dx.doi.org/10.1093/nar/gkw468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937333/
https://www.ncbi.nlm.nih.gov/pubmed/27220468
http://dx.doi.org/10.1093/nar/gkw468

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