The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA

The template-directed incorporation of nucleotides at the terminus of a growing primer is the basis of the transmission of genetic information. Nature uses polymerases-catalyzed reactions, but enzyme-free versions exist that employ nucleotides with organic leaving groups. The leaving group affects y...

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Detalles Bibliográficos
Autores principales: Kervio, Eric, Sosson, Marilyne, Richert, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937335/
https://www.ncbi.nlm.nih.gov/pubmed/27235418
http://dx.doi.org/10.1093/nar/gkw476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937335/
https://www.ncbi.nlm.nih.gov/pubmed/27235418
http://dx.doi.org/10.1093/nar/gkw476

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