A Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses

RIG-I is an essential receptor in the initiation of the type I interferon (IFN) signaling pathway upon viral infection. Although K63-linked ubiquitination plays an important role in RIG-I activation, the optimal modulation of conjugated and unanchored ubiquitination of RIG-I as well as its functiona...

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Detalles Bibliográficos
Autores principales: Sun, Xiaoqiang, Xian, Huifang, Tian, Shuo, Sun, Tingzhe, Qin, Yunfei, Zhang, Shoutao, Cui, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937349/
https://www.ncbi.nlm.nih.gov/pubmed/27387525
http://dx.doi.org/10.1038/srep29263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937349/
https://www.ncbi.nlm.nih.gov/pubmed/27387525
http://dx.doi.org/10.1038/srep29263

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