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Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies

Abnormal α-synuclein (α-syn) accumulation in the CNS may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Multiple groups demonstrated α-syn accumulation in CNS accesso...

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Detalles Bibliográficos
Autores principales: Price, Diana L., Rockenstein, Edward, Mante, Michael, Adame, Anthony, Overk, Cassia, Spencer, Brian, Duong-Polk, Karen X., Bonhaus, Douglas, Lindsey, James, Masliah, Eliezer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937425/
https://www.ncbi.nlm.nih.gov/pubmed/27389831
http://dx.doi.org/10.1038/srep29523