Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

Transcription factors regulate their target genes by binding to regulatory regions in the genome. Although the binding preferences of TP53 are known, it remains unclear what distinguishes functional enhancers from nonfunctional binding. In addition, the genome is scattered with recognition sequences...

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Detalles Bibliográficos
Autores principales: Verfaillie, Annelien, Svetlichnyy, Dmitry, Imrichova, Hana, Davie, Kristofer, Fiers, Mark, Kalender Atak, Zeynep, Hulselmans, Gert, Christiaens, Valerie, Aerts, Stein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937571/
https://www.ncbi.nlm.nih.gov/pubmed/27197205
http://dx.doi.org/10.1101/gr.204149.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937571/
https://www.ncbi.nlm.nih.gov/pubmed/27197205
http://dx.doi.org/10.1101/gr.204149.116

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