Cargando…

Absolute bioavailability and regional absorption of ticagrelor in healthy volunteers

OBJECTIVE: Ticagrelor is a direct-acting, reversibly-binding, oral P2Y(12) receptor antagonist. It demonstrates predictable, linear pharmacokinetics. Two studies were undertaken to further elucidate the absolute bioavailability of ticagrelor and its regional absorption in the gastrointestinal (GI) t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teng, Renli, Maya, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937635/ https://www.ncbi.nlm.nih.gov/pubmed/27536453 http://dx.doi.org/10.3109/21556660.2014.946604

Ejemplares similares

Evaluation of the pharmacokinetics and pharmacodynamics of ticagrelor co-administered with aspirin in healthy volunteers
por: Teng, Renli, et al.
Publicado: (2013)

An open-label, randomized bioavailability study with alternative methods of administration of crushed ticagrelor tablets in healthy volunteers
por: Teng, Renli, et al.
Publicado: (2015)

Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers
por: Teng, Renli, et al.
Publicado: (2013)

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age
por: Kumar, Vipul, et al.
Publicado: (2019)

New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers
por: Moghadamnia, Yasaman, et al.
Publicado: (2019)

Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update
por: Teng, Renli
Publicado: (2015)

Absolute Oral Bioavailability of Glasdegib (PF‐04449913), a Smoothened Inhibitor, in Randomized Healthy Volunteers
por: Shaik, Naveed, et al.
Publicado: (2019)

Pharmacokinetic Profiles of Ticagrelor Orodispersible Tablets in Healthy Western and Japanese Subjects
por: Teng, Renli, et al.
Publicado: (2017)

Relative and Absolute Bioavailability Study of Emicizumab to Bridge Drug Products and Subcutaneous Injection Sites in Healthy Volunteers
por: Kotani, Naoki, et al.
Publicado: (2018)

Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals
por: Kvitne, Kine Eide, et al.
Publicado: (2023)

Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers
por: Inoue, Yushi, et al.
Publicado: (2012)

Phenotypic differences in nebivolol metabolism and bioavailability in healthy volunteers
por: BRICIU, CORINA, et al.
Publicado: (2015)

Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion, and absolute bioavailability in healthy participants
por: Ucpinar, Sibel, et al.
Publicado: (2023)

A randomised trial of the pharmacodynamic and pharmacokinetic effects of ticagrelor compared with clopidogrel in Hispanic patients with stable coronary artery disease
por: Price, Matthew J., et al.
Publicado: (2014)

Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers
por: Buszko, Katarzyna, et al.
Publicado: (2021)

Effect of CYP4F2 Polymorphisms on Ticagrelor Pharmacokinetics in Healthy Chinese Volunteers
por: Nie, Shanshan, et al.
Publicado: (2022)

Absorption, metabolism and excretion of opicapone in human healthy volunteers
por: Loureiro, Ana I., et al.
Publicado: (2022)

Oral bioavailability and pharmacokinetic study of cetrizine HCl in Iranian healthy volunteers
por: Derakhshandeh, K., et al.
Publicado: (2009)

Absolute and Trend Accuracy of a New Regional Oximeter in Healthy Volunteers During Controlled Hypoxia
por: Redford, Daniel, et al.
Publicado: (2014)

Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers
por: Pawar, Yogesh B., et al.
Publicado: (2012)

Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers
por: Parikh, Neha, et al.
Publicado: (2016)

Bioavailability and swallowability of an age-appropriate, delayed-release mesalamine formulation in healthy volunteers
por: Jakate, Abhijeet, et al.
Publicado: (2019)

Pharmacokinetics and pharmacodynamics of ticagrelor in subjects on hemodialysis and subjects with normal renal function
por: Teng, Renli, et al.
Publicado: (2018)

Bioavailability of Epigallocatechin Gallate Administered with Different Nutritional Strategies in Healthy Volunteers
por: Andreu Fernández, Vicente, et al.
Publicado: (2020)

Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers
por: Anlamlert, Wirin, et al.
Publicado: (2020)

The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
por: Sornsuvit, Chuleegone, et al.
Publicado: (2018)

Open-label, single-center, phase I trial to investigate the mass balance and absolute bioavailability of the highly selective oral MET inhibitor tepotinib in healthy volunteers
por: Johne, Andreas, et al.
Publicado: (2020)

The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [(14)C]-BI 425809 in Healthy Males
por: Burkard, Ute, et al.
Publicado: (2021)

Single- and Multiple-Dose Pharmacokinetics and Absolute Bioavailability of Tedizolid
por: Flanagan, Shawn, et al.
Publicado: (2014)

Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers
por: Ikuta, Naoko, et al.
Publicado: (2016)

Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers
por: Russo, Rosario, et al.
Publicado: (2018)

Differential Effects of Ticagrelor With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers
por: Traby, Ludwig, et al.
Publicado: (2019)

Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers
por: Hogan, R. Edward, et al.
Publicado: (2020)

The stable isotope method for determining absolute bioavailability
por: Atkinson, Arthur J.
Publicado: (2017)

Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation
por: Zaid, Abdel Naser, et al.
Publicado: (2015)

Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers
por: Xing, Lu, et al.
Publicado: (2017)

Relative Bioavailability of Fentanyl Following Various Dosing Regimens of Fentanyl Buccal Tablet in Healthy Japanese Volunteers
por: Darwish, Mona, et al.
Publicado: (2008)

Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers
por: Bashar, Tafsir, et al.
Publicado: (2018)

Relative bioavailability of a pediatric dispersible tablet and adult film‐coated tablet of macitentan in healthy volunteers
por: Sidharta, Patricia N., et al.
Publicado: (2020)

594. An Open-Label Study in Healthy Volunteers to Determine the Absolute Bioavailability of, the Effect of Food and Dosing by Nasogastric Tube upon the Pharmacokinetics of a Single Oral Dose of Olorofim (OLO)
por: Cornelissen, Karen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fd2d2rqmmsj20dogenl22qqk9l