Metabolism of the prodrug lisdexamfetamine dimesylate in human red blood cells from normal and sickle cell disease donors*

OBJECTIVES: Lisdexamfetamine dimesylate (LDX), a long-acting pro-drug psychostimulant, requires conversion to d-amphetamine for therapeutic activity. Conversion of LDX to d-amphetamine occurs primarily in the blood, specifically red blood cells (RBCs). These in vitro studies examine potential conver...

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Detalles Bibliográficos
Autor principal: Pennick, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Maney Publishing 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937656/
https://www.ncbi.nlm.nih.gov/pubmed/27536433
http://dx.doi.org/10.3109/21556660.2013.775132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937656/
https://www.ncbi.nlm.nih.gov/pubmed/27536433
http://dx.doi.org/10.3109/21556660.2013.775132

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