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Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio (non-homology-based) structure prediction. Such m...

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Detalles Bibliográficos
Autores principales: Simkovic, Felix, Thomas, Jens M. H., Keegan, Ronan M., Winn, Martyn D., Mayans, Olga, Rigden, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937781/
https://www.ncbi.nlm.nih.gov/pubmed/27437113
http://dx.doi.org/10.1107/S2052252516008113