Cargando…

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade

RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid carcinomas where both germline and sporadic activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Watson, Amanda J., Hopkins, Gemma V., Hitchin, Samantha, Begum, Habiba, Jones, Stuart, Jordan, Allan, Holt, Sarah, March, H. Nikki, Newton, Rebecca, Small, Helen, Stowell, Alex, Waddell, Ian D., Waszkowycz, Bohdan, Ogilvie, Donald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937820/
https://www.ncbi.nlm.nih.gov/pubmed/27429741
http://dx.doi.org/10.12688/f1000research.8724.2