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Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade
RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid carcinomas where both germline and sporadic activa...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937820/ https://www.ncbi.nlm.nih.gov/pubmed/27429741 http://dx.doi.org/10.12688/f1000research.8724.2 |