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Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels
K(ATP) channels act as key regulators of electrical excitability by coupling metabolic cues—mainly intracellular adenine nucleotide concentrations—to cellular potassium ion efflux. However, their study has been hindered by their rapid loss of activity in excised membrane patches (rundown), and by a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938026/ https://www.ncbi.nlm.nih.gov/pubmed/27377720 http://dx.doi.org/10.1098/rstb.2015.0426 |