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Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels

K(ATP) channels act as key regulators of electrical excitability by coupling metabolic cues—mainly intracellular adenine nucleotide concentrations—to cellular potassium ion efflux. However, their study has been hindered by their rapid loss of activity in excised membrane patches (rundown), and by a...

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Detalles Bibliográficos
Autores principales:	Proks, Peter, Puljung, Michael C., Vedovato, Natascia, Sachse, Gregor, Mulvaney, Rachel, Ashcroft, Frances M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938026/ https://www.ncbi.nlm.nih.gov/pubmed/27377720 http://dx.doi.org/10.1098/rstb.2015.0426

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