Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1

Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but...

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Detalles Bibliográficos
Autores principales: Lee, Siyoung, Kim, Eunsom, Jhun, Hyunjhung, Hong, Jaewoo, Kwak, Areum, Jo, Seunghyun, Bae, Suyoung, Lee, Jongho, Kim, Busun, Lee, Jungmin, Youn, Sulah, Kim, Somi, Kim, Miyeon, Kim, Hyunwoo, Lee, Youngmin, Choi, Dong-Ki, Kim, Yong-Sung, Kim, Soohyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938183/
https://www.ncbi.nlm.nih.gov/pubmed/27226621
http://dx.doi.org/10.1074/jbc.M116.731026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938183/
https://www.ncbi.nlm.nih.gov/pubmed/27226621
http://dx.doi.org/10.1074/jbc.M116.731026

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