Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors

Engineering potent bispecific antibodies from single-chain variable fragments (scFv) remains difficult due to the inherent instability and insufficient binding of scFv's compared to their parental immunoglobulin format. Previously, we described a scFv-based bispecific antibody (scBA) against di...

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Detalles Bibliográficos
Autores principales: Cheng, Ming, Santich, Brian H., Xu, Hong, Ahmed, Mahiuddin, Huse, Morgan, Cheung, Nai-Kong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938304/
https://www.ncbi.nlm.nih.gov/pubmed/27471647
http://dx.doi.org/10.1080/2162402X.2016.1168557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938304/
https://www.ncbi.nlm.nih.gov/pubmed/27471647
http://dx.doi.org/10.1080/2162402X.2016.1168557

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