Beyond Oncolytics: E1B55K-Deleted Adenovirus as a Vaccine Delivery Vector

Type 5 human adenoviruses (Ad5) deleted of genes encoding the early region 1B 55-kDa (E1B55K) protein including Onyx-015 (dl1520) and H101 are best known for their oncolytic potential. As a vaccine vector the E1B55K deletion may allow for the insertion of a transgene nearly 1,000 base pairs larger t...

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Detalles Bibliográficos
Autores principales: Thomas, Michael A., Nyanhete, Tinashe, Tuero, Iskra, Venzon, David, Robert-Guroff, Marjorie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938603/
https://www.ncbi.nlm.nih.gov/pubmed/27391605
http://dx.doi.org/10.1371/journal.pone.0158505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938603/
https://www.ncbi.nlm.nih.gov/pubmed/27391605
http://dx.doi.org/10.1371/journal.pone.0158505

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