Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Genetic heterogeneity contributes to clinical outcome and progression of most tumors. Yet, little is known regarding allelic diversity for epigenetic compartments and almost no data exists for acute myeloid leukemia (AML). Here we examined epigenetic heterogeneity as assessed by cytosine methylation...

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Detalles Bibliográficos
Autores principales: Li, Sheng, Garrett-Bakelman, Francine E., Chung, Stephen S., Sanders, Mathijs A., Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L., Perl, Alexander E., Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D., To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L., Hassane, Duane C., Roboz, Gail J., Grimwade, David, Valk, Peter J.M., D’Andrea, Richard J., Carroll, Martin, Park, Christopher Y., Neuberg, Donna, Levine, Ross, Melnick, Ari M., Mason, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938719/
https://www.ncbi.nlm.nih.gov/pubmed/27322744
http://dx.doi.org/10.1038/nm.4125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938719/
https://www.ncbi.nlm.nih.gov/pubmed/27322744
http://dx.doi.org/10.1038/nm.4125

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