Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable

BACKGROUND: While commonly assumed in the biochemistry community that the control of metabolic pathways is thought to be critical to cellular function, it is unclear if metabolic pathways generally have evolutionarily stable rate limiting (flux controlling) steps. RESULTS: A set of evolutionary simu...

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Detalles Bibliográficos
Autores principales: Orlenko, Alena, Teufel, Ashley I., Chi, Peter B., Liberles, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938953/
https://www.ncbi.nlm.nih.gov/pubmed/27393343
http://dx.doi.org/10.1186/s13062-016-0133-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938953/
https://www.ncbi.nlm.nih.gov/pubmed/27393343
http://dx.doi.org/10.1186/s13062-016-0133-6

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