Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S. The prepared analogues were evaluated for their...

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Detalles Bibliográficos
Autores principales: Abadi, Ashraf H., Lehmann, Jochen, Piazza, Gary A., Abdel-Halim, Mohammad, Ali, Mohamed S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939265/
https://www.ncbi.nlm.nih.gov/pubmed/27471602
http://dx.doi.org/10.1155/2011/562421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939265/
https://www.ncbi.nlm.nih.gov/pubmed/27471602
http://dx.doi.org/10.1155/2011/562421

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