Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers

BACKGROUND: Down syndrome incidence in humans increases dramatically with maternal age. This is mainly the result of increased meiotic errors, but factors such as differences in abortion rate may play a role as well. Since the meiotic error rate increases almost exponentially after a certain age, it...

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Detalles Bibliográficos
Autores principales: Stern, Shani, Biron, David, Moses, Elisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939633/
https://www.ncbi.nlm.nih.gov/pubmed/27401751
http://dx.doi.org/10.1186/s12863-016-0412-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939633/
https://www.ncbi.nlm.nih.gov/pubmed/27401751
http://dx.doi.org/10.1186/s12863-016-0412-3

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