In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)

BACKGROUND: Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Studies in animal models have shown a low concentration in the brain following systemic injection. METHODS: To assess 2-PAM tran...

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Detalles Bibliográficos
Autores principales: Gallagher, Erin, Minn, Il, Chambers, Janice E., Searson, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939658/
https://www.ncbi.nlm.nih.gov/pubmed/27396356
http://dx.doi.org/10.1186/s12987-016-0035-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939658/
https://www.ncbi.nlm.nih.gov/pubmed/27396356
http://dx.doi.org/10.1186/s12987-016-0035-0

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