A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production

Human pluripotent stem cells (hPSCs) exist in heterogeneous micro-environments with multiple subpopulations, convoluting fate-regulation analysis. We patterned hPSCs into engineered micro-environments and screened responses to 400 small-molecule kinase inhibitors, measuring yield and purity outputs...

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Detalles Bibliográficos
Autores principales: Nazareth, Emanuel Joseph Paul, Rahman, Nafees, Yin, Ting, Zandstra, Peter William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939733/
https://www.ncbi.nlm.nih.gov/pubmed/27132889
http://dx.doi.org/10.1016/j.stemcr.2016.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939733/
https://www.ncbi.nlm.nih.gov/pubmed/27132889
http://dx.doi.org/10.1016/j.stemcr.2016.04.003

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