Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation

Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic AMP (cAMP) induction dramatically increases HSC-...

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Detalles Bibliográficos
Autores principales: Saxena, Shobhit, Rönn, Roger E., Guibentif, Carolina, Moraghebi, Roksana, Woods, Niels-Bjarne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939749/
https://www.ncbi.nlm.nih.gov/pubmed/27117782
http://dx.doi.org/10.1016/j.stemcr.2016.03.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939749/
https://www.ncbi.nlm.nih.gov/pubmed/27117782
http://dx.doi.org/10.1016/j.stemcr.2016.03.006

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