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MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells
Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regula...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939759/ https://www.ncbi.nlm.nih.gov/pubmed/27150236 http://dx.doi.org/10.1016/j.stemcr.2016.03.005 |