High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells

Canonical Wnt signaling regulates the self-renewal of most if not all stem cell systems. In the blood system, the role of Wnt signaling has been the subject of much debate but there is consensus that high Wnt signals lead to loss of reconstituting capacity. To better understand this phenomenon, we h...

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Detalles Bibliográficos
Autores principales: Famili, Farbod, Brugman, Martijn H., Taskesen, Erdogan, Naber, Brigitta E.A., Fodde, Riccardo, Staal, Frank J.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939829/
https://www.ncbi.nlm.nih.gov/pubmed/27167156
http://dx.doi.org/10.1016/j.stemcr.2016.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939829/
https://www.ncbi.nlm.nih.gov/pubmed/27167156
http://dx.doi.org/10.1016/j.stemcr.2016.04.009

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