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Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression
Half of human genome is made of repetitive DNA. However, mechanisms underlying replication of chromosome regions containing repetitive DNA are poorly understood. We reconstituted replication of defined human chromosome segments using Bacterial Artificial Chromosomes (BACs) in Xenopus laevis egg extr...
Autores principales: | Aze, Antoine, Sannino, Vincenzo, Soffientini, Paolo, Bachi, Angela, Costanzo, Vincenzo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939857/ https://www.ncbi.nlm.nih.gov/pubmed/27111843 http://dx.doi.org/10.1038/ncb3344 |
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