Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts

Bcl-xL proteins undergo dynamic phosphorylation/dephosphorylation on Ser49 and Ser62 residues during mitosis. The expression of Bcl-xL(S49A), (S62A) and dual (S49/62A) phosphorylation mutants in tumor cells lead to severe mitotic defects associated with multipolar spindle, chromosome lagging and bri...

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Detalles Bibliográficos
Autores principales: Baruah, Prasamit Saurav, Beauchemin, Myriam, Hébert, Josée, Bertrand, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939973/
https://www.ncbi.nlm.nih.gov/pubmed/27398719
http://dx.doi.org/10.1371/journal.pone.0159091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939973/
https://www.ncbi.nlm.nih.gov/pubmed/27398719
http://dx.doi.org/10.1371/journal.pone.0159091

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