Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

BACKGROUND: The replacement of hydrogen with deuterium invokes a kinetic isotope effect. Thus, this method is an attractive way to slow down the metabolic rate and modulate pharmacokinetics. PURPOSE: Enzalutamide (ENT) acts as a competitive inhibitor of the androgen receptor and has been approved fo...

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Detalles Bibliográficos
Autores principales: Jiang, Jinfang, Pang, Xuehai, Li, Liang, Dai, Xiaojian, Diao, Xingxing, Chen, Xiaoyan, Zhong, Dafang, Wang, Yingwei, Chen, Yuanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939996/
https://www.ncbi.nlm.nih.gov/pubmed/27462143
http://dx.doi.org/10.2147/DDDT.S111352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939996/
https://www.ncbi.nlm.nih.gov/pubmed/27462143
http://dx.doi.org/10.2147/DDDT.S111352

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