Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13

Binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its receptor C-X-C chemokine receptor type 4 (CXCR4) results in receptor activation and the subsequent release of matrix metalloproteinases (MMPs) that contribute to osteoarthritis (OA) cartilage degradation. As hypoxia is a defining...

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Detalles Bibliográficos
Autores principales: Li, Pengcui, Deng, Jin, Wei, Xiaochun, Jayasuriya, Chathuraka T., Zhou, Jingming, Chen, Qian, Zhang, Jianzhong, Wei, Lei, Wei, Fangyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940083/
https://www.ncbi.nlm.nih.gov/pubmed/27356492
http://dx.doi.org/10.3892/mmr.2016.5419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940083/
https://www.ncbi.nlm.nih.gov/pubmed/27356492
http://dx.doi.org/10.3892/mmr.2016.5419

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