Architecture and RNA binding of the human negative elongation factor

Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we discern the functional architecture of human NELF through X-ray crystallography, protein crosslinking, biochemical assays...

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Detalles Bibliográficos
Autores principales: Vos, Seychelle M, Pöllmann, David, Caizzi, Livia, Hofmann, Katharina B, Rombaut, Pascaline, Zimniak, Tomasz, Herzog, Franz, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940160/
https://www.ncbi.nlm.nih.gov/pubmed/27282391
http://dx.doi.org/10.7554/eLife.14981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940160/
https://www.ncbi.nlm.nih.gov/pubmed/27282391
http://dx.doi.org/10.7554/eLife.14981

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