Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3–300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrag...

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Detalles Bibliográficos
Autores principales: Bednarczyk-Cwynar, Barbara, Wachowiak, Natalia, Szulc, Michal, Kamińska, Ewa, Bogacz, Anna, Bartkowiak-Wieczorek, Joanna, Zaprutko, Lucjusz, Mikolajczak, Przemyslaw L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940421/
https://www.ncbi.nlm.nih.gov/pubmed/27462270
http://dx.doi.org/10.3389/fphar.2016.00202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940421/
https://www.ncbi.nlm.nih.gov/pubmed/27462270
http://dx.doi.org/10.3389/fphar.2016.00202

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