Cargando…

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3–300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bednarczyk-Cwynar, Barbara, Wachowiak, Natalia, Szulc, Michal, Kamińska, Ewa, Bogacz, Anna, Bartkowiak-Wieczorek, Joanna, Zaprutko, Lucjusz, Mikolajczak, Przemyslaw L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940421/ https://www.ncbi.nlm.nih.gov/pubmed/27462270 http://dx.doi.org/10.3389/fphar.2016.00202

Ejemplares similares

Simple Amides of Oleanolic Acid as Effective Penetration Enhancers
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2015)

The Effect of Oleanolic Acid and Its Four New Semisynthetic Derivatives on Human MeWo and A375 Melanoma Cell Lines
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2023)

Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR
por: Lisiak, Natalia, et al.
Publicado: (2023)

Recent advances in synthesis and biological activity of triterpenic acylated oximes
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2014)

Oleanolic Acid’s Semisynthetic Derivatives HIMOXOL and Br-HIMOLID Show Proautophagic Potential and Inhibit Migration of HER2-Positive Breast Cancer Cells In Vitro
por: Lisiak, Natalia Magdalena, et al.
Publicado: (2021)

Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives
por: Pawełczyk, Anna, et al.
Publicado: (2016)

3β-Acetoxy-12α-chloro-d-friedooleanan-28,14β-olide
por: Froelich, Anna, et al.
Publicado: (2011)

Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
por: Loboda, Agnieszka, et al.
Publicado: (2012)

Synthesis, Cytotoxicity and Molecular Docking of New Hybrid Compounds by Combination of Curcumin with Oleanolic Acid
por: Sowa-Kasprzak, Katarzyna, et al.
Publicado: (2023)

Polymorphism of Butyl Ester of Oleanolic Acid—The Dominance of Dispersive Interactions over Electrostatic
por: Langer, Dominik, et al.
Publicado: (2023)

The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells
por: Narożna, Maria, et al.
Publicado: (2020)

The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model
por: Bogacz, Anna, et al.
Publicado: (2014)

Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action
por: Ozarowski, Marcin, et al.
Publicado: (2016)

Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties
por: Rali, Sibusiso, et al.
Publicado: (2016)

Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study
por: Ozarowski, Marcin, et al.
Publicado: (2015)

Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives
por: Pawełczyk, Anna, et al.
Publicado: (2020)

The Effect of Different Water Extracts from Platycodon grandiflorum on Selected Factors Associated with Pathogenesis of Chronic Bronchitis in Rats
por: Buchwald, Waldemar, et al.
Publicado: (2020)

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates
por: Kaminskyy, Danylo, et al.
Publicado: (2011)

Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential
por: Narożna, Maria, et al.
Publicado: (2021)

Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.
por: Mikołajczak, Przemysław Łukasz, et al.
Publicado: (2016)

Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines
por: Olender, Dorota, et al.
Publicado: (2018)

Molecular Consortia—Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis
por: Pawełczyk, Anna, et al.
Publicado: (2018)

Microwave (MW), Ultrasound (US) and Combined Synergic MW-US Strategies for Rapid Functionalization of Pharmaceutical Use Phenols
por: Pawełczyk, Anna, et al.
Publicado: (2018)

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla
por: Vinh, Le Ba, et al.
Publicado: (2020)

Ultramicronized N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception
por: Di Cesare Mannelli, Lorenzo, et al.
Publicado: (2018)

Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity
por: Mo, Wei-bin, et al.
Publicado: (2016)

Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
por: Baer-Dubowska, Wanda, et al.
Publicado: (2021)

Novel Molecular Consortia of Cannabidiol with Nonsteroidal Anti-Inflammatory Drugs Inhibit Emerging Coronaviruses’ Entry
por: Pawełczyk, Anna, et al.
Publicado: (2023)

Oleanolic acid ethanol monosolvate
por: Froelich, Anna, et al.
Publicado: (2010)

Differential Influence of Pueraria lobata Root Extract and Its Main Isoflavones on Ghrelin Levels in Alcohol-Treated Rats
por: Szulc, Michał, et al.
Publicado: (2021)

Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities
por: Tang, Liyao, et al.
Publicado: (2023)

Combined Effects of Methyldopa and Flavonoids on the Expression of Selected Factors Related to Inflammatory Processes and Vascular Diseases in Human Placenta Cells—An In Vitro Study
por: Bogacz, Anna, et al.
Publicado: (2021)

Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
por: Kurek, Joanna, et al.
Publicado: (2021)

Curcumin–Triterpene Type Hybrid as Effective Sonosensitizers for Sonodynamic Therapy in Oral Squamous Cell Carcinoma
por: Sowa-Kasprzak, Katarzyna, et al.
Publicado: (2023)

PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain
por: Hurt, Julie K, et al.
Publicado: (2012)

Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation
por: Kanda, Hirosato, et al.
Publicado: (2021)

3-Cyano-11-oxo-3,4-seco-12a-aza-C-homoolean-4(23)-en-28-oic acid methyl ester
por: Froelich, A., et al.
Publicado: (2012)

The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer
por: Mrozikiewicz-Rakowska, Beata, et al.
Publicado: (2019)

Recent advances in nanoparticle formulation of oleanolic acid
por: Chen, Meiwan, et al.
Publicado: (2011)

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update
por: Jesus, Jéssica A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eeicrnm3qf0jlk75vh9781ah9f