Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches

The nucleoprotein (NP) of Ebola virus (EBOV) and Marburg virus (MARV) is an essential component of the viral ribonucleoprotein complex and significantly impacts replication and transcription of the viral RNA genome. Although NP is regarded as a promising antiviral druggable target, no chemical ligan...

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Detalles Bibliográficos
Autores principales: Fu, Xu, Wang, Zhihua, Li, Lixin, Dong, Shishang, Li, Zhucui, Jiang, Zhenzuo, Wang, Yuefei, Shui, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940736/
https://www.ncbi.nlm.nih.gov/pubmed/27403722
http://dx.doi.org/10.1038/srep29680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940736/
https://www.ncbi.nlm.nih.gov/pubmed/27403722
http://dx.doi.org/10.1038/srep29680

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