Iron(II) supramolecular helicates interfere with the HIV-1 Tat–TAR RNA interaction critical for viral replication

The interaction between the HIV-1 transactivator protein Tat and TAR (transactivation responsive region) RNA, plays a critical role in HIV-1 transcription. Iron(II) supramolecular helicates were evaluated for their in vitro activity to inhibit Tat–TAR RNA interaction using UV melting studies, electr...

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Detalles Bibliográficos
Autores principales: Malina, Jaroslav, Hannon, Michael J., Brabec, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940744/
https://www.ncbi.nlm.nih.gov/pubmed/27405089
http://dx.doi.org/10.1038/srep29674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940744/
https://www.ncbi.nlm.nih.gov/pubmed/27405089
http://dx.doi.org/10.1038/srep29674

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