Highly sensitive detection of the PIK3CA(H1047R) mutation in colorectal cancer using a novel PCR-RFLP method

BACKGROUND: The PIK3CA(H1047R) mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CA(H1047R) mutation in high effectiveness. METHODS: A 126-bp fragment of PIK3CA exon-20 was amplified by P...

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Detalles Bibliográficos
Autores principales: Li, Wan-Ming, Hu, Ting-Ting, Zhou, Lin-Lin, Feng, Yi-Ming, Wang, Yun-Yi, Fang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941018/
https://www.ncbi.nlm.nih.gov/pubmed/27405731
http://dx.doi.org/10.1186/s12885-016-2493-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941018/
https://www.ncbi.nlm.nih.gov/pubmed/27405731
http://dx.doi.org/10.1186/s12885-016-2493-9

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