Cargando…

Highly sensitive detection of the PIK3CA(H1047R) mutation in colorectal cancer using a novel PCR-RFLP method

BACKGROUND: The PIK3CA(H1047R) mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CA(H1047R) mutation in high effectiveness. METHODS: A 126-bp fragment of PIK3CA exon-20 was amplified by P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wan-Ming, Hu, Ting-Ting, Zhou, Lin-Lin, Feng, Yi-Ming, Wang, Yun-Yi, Fang, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941018/ https://www.ncbi.nlm.nih.gov/pubmed/27405731 http://dx.doi.org/10.1186/s12885-016-2493-9

Ejemplares similares

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin
por: Cufí, Sílvia, et al.
Publicado: (2013)

Identification of effective natural PIK3CA H1047R inhibitors by computational study
por: Liu, Naimeng, et al.
Publicado: (2021)

Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant
por: Gkeka, Paraskevi, et al.
Publicado: (2014)

PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAF(V600E) PIK3CA(H1047R) double mutant thyroid tumors
por: Roelli, Matthias A., et al.
Publicado: (2017)

Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
por: Yuan, W, et al.
Publicado: (2013)

Recurrent PIK3CA H1047R-Mutated Congenital Infiltrative Facial Lipomatosis: A Case Report and Review of Literature
por: Oh, Kei Shing, et al.
Publicado: (2023)

Generation of a tree shrew breast cancer model using lentivirus expressing PIK3CA-H1047R
por: Zeng, Li, et al.
Publicado: (2023)

Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation
por: Bleckmann, Annalen, et al.
Publicado: (2020)

Somatic Mutation of PIK3CA (H1047R) Is a Common Driver Mutation Hotspot in Canine Mammary Tumors as Well as Human Breast Cancers
por: Lee, Kang-Hoon, et al.
Publicado: (2019)

Everolimus in hormone receptor-positive metastatic breast cancer: PIK3CA mutation H1047R was a potential efficacy biomarker in a retrospective study
por: Yi, Zongbi, et al.
Publicado: (2019)

DMBA induced mouse mammary tumors display high incidence of activating Pik3ca(H1047) and loss of function Pten mutations
por: Abba, Martín C., et al.
Publicado: (2016)

A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation
por: Kalofonou, Melpomeni, et al.
Publicado: (2020)

Physiological Levels of Pik3ca (H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors
por: Tikoo, Anjali, et al.
Publicado: (2012)

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA(H1047R) homozygosity in pluripotent stem cells
por: Madsen, Ralitsa R., et al.
Publicado: (2021)

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis
por: Yuan, Wenlin, et al.
Publicado: (2019)

PIK3CA(H1047R) and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling
por: Cheng, Hailing, et al.
Publicado: (2015)

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R
por: Meyer, D S, et al.
Publicado: (2013)

PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane–Based Neoadjuvant Chemotherapy
por: Guo, Sanxing, et al.
Publicado: (2020)

The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K–Akt Pathways
por: Candido, Saverio, et al.
Publicado: (2022)

PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer
por: Wang, Qiang, et al.
Publicado: (2018)

Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers
por: Engelman, Jeffrey A., et al.
Publicado: (2008)

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
por: Chen, Li, et al.
Publicado: (2018)

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited
por: Hall, Daniella C. N., et al.
Publicado: (2022)

PCR-RFLP of mitochondrial DNA reveals two origins of Apis mellifera in Taiwan
por: Wu, Ming-Cheng, et al.
Publicado: (2017)

PIK3CA mutation and colorectal cancer precision medicine
por: Hamada, Tsuyoshi, et al.
Publicado: (2017)

PIK3CA in Colorectal Cancer
por: Cathomas, Gieri
Publicado: (2014)

Prevalence and characteristics of PIK3CA mutation in mismatch repair-deficient colorectal cancer
por: Li, Weihua, et al.
Publicado: (2020)

The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells
por: Wan, G, et al.
Publicado: (2015)

Mutations of PIK3CA in gastric adenocarcinoma
por: Li, Vivian Sze Wing, et al.
Publicado: (2005)

Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA
por: Chang, Li-Chun, et al.
Publicado: (2014)

Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition
por: Boku, Shogen, et al.
Publicado: (2020)

Characterization of Genomic Inheritance of Intergeneric Hybrids between Ascocenda and Phalaenopsis Cultivars by GISH, PCR-RFLP and RFLP
por: Liu, Wen-Lin, et al.
Publicado: (2016)

Development of a multiplex allele-specific qPCR approach for testing PIK3CA mutations in patients with colorectal cancer
por: Oscorbin, Igor P., et al.
Publicado: (2022)

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K
por: Yueh, Alexander E., et al.
Publicado: (2016)

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
por: Hao, Yujun, et al.
Publicado: (2016)

The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients
por: Fu, Xinhui, et al.
Publicado: (2021)

The Genomic Environment of BRAF Mutated and BRAF/PIK3CA Double Mutated Colorectal Cancers
por: Voutsadakis, Ioannis A.
Publicado: (2022)

Mutations in PIK3CA are infrequent in neuroblastoma
por: Dam, Vincent, et al.
Publicado: (2006)

PIK3CA-mutations in breast cancer
por: Reinhardt, Kristin, et al.
Publicado: (2022)

Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer
por: Christenson, Eric S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ntksjgrankacnbe1b98ngvmt4d