A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models

Single-chain variable fragments (scFvs) expressed as “intracellular antibodies” (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. Here we use an intrabody targeting the E6 oncoprotein of Human papillomavirus 16 (HPV16) to address the issue of a...

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Detalles Bibliográficos
Autores principales: Amici, Carla, Visintin, Michela, Verachi, Francesca, Paolini, Francesca, Percario, Zulema, Di Bonito, Paola, Mandarino, Angela, Affabris, Elisabetta, Venuti, Aldo, Accardi, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941259/
https://www.ncbi.nlm.nih.gov/pubmed/26788990
http://dx.doi.org/10.18632/oncotarget.6925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941259/
https://www.ncbi.nlm.nih.gov/pubmed/26788990
http://dx.doi.org/10.18632/oncotarget.6925

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