The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11

Adenovirus-mediated sensitization of cancer cells to cytotoxic drugs depends on simultaneous interactions of early viral genes with cell death and survival pathways. It is unclear what cellular factors mediate these interactions in the presence of DNA-damaging drugs. We found that adenovirus prevent...

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Detalles Bibliográficos
Autores principales: Pantelidou, Constantia, Cherubini, Gioia, Lemoine, Nick R., Halldén, Gunnel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941271/
https://www.ncbi.nlm.nih.gov/pubmed/26872382
http://dx.doi.org/10.18632/oncotarget.7310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941271/
https://www.ncbi.nlm.nih.gov/pubmed/26872382
http://dx.doi.org/10.18632/oncotarget.7310

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