Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA

BH3 mimetic compounds induce tumor cell death through targeted inhibition of anti-apoptotic BCL2 proteins. Resistance to one such compound, ABT-737, is due to increased levels of anti-apoptotic MCL1. Using chemical and genetic approaches, we show that resistance to ABT-737 is abrogated by inhibition...

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Detalles Bibliográficos
Autores principales: Subramanian, Aishwarya, Andronache, Adrian, Li, Yao-Cheng, Wade, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941292/
https://www.ncbi.nlm.nih.gov/pubmed/26910119
http://dx.doi.org/10.18632/oncotarget.7558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941292/
https://www.ncbi.nlm.nih.gov/pubmed/26910119
http://dx.doi.org/10.18632/oncotarget.7558

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