Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer

MDM2 and MDM4 are heterodimeric, non-redundant oncoproteins that potently inhibit the p53 tumor suppressor protein. MDM2 and MDM4 also enhance the tumorigenicity of breast cancer cells in in vitro and in vivo models and are overexpressed in primary human breast cancers. Prior studies have characteri...

Descripción completa

Detalles Bibliográficos
Autores principales: Swetzig, Wendy M., Wang, Jianmin, Das, Gokul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941297/
https://www.ncbi.nlm.nih.gov/pubmed/26909605
http://dx.doi.org/10.18632/oncotarget.7533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941297/
https://www.ncbi.nlm.nih.gov/pubmed/26909605
http://dx.doi.org/10.18632/oncotarget.7533

Ejemplares similares