AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin

AMP-activated protein kinase (AMPK) is an important energy sensor that may inhibit cell proliferation or promote cell survival during stresses. Besides cyclooxygenase, AMPK is another target of the nonsteroid anti-inflammatory agent aspirin. Preclinical and clinical investigations demonstrate that a...

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Detalles Bibliográficos
Autores principales: Gao, Mei, Kong, Qingbin, Hua, Hui, Yin, Yancun, Wang, Jiao, Luo, Ting, Jiang, Yangfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941319/
https://www.ncbi.nlm.nih.gov/pubmed/26918349
http://dx.doi.org/10.18632/oncotarget.7648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941319/
https://www.ncbi.nlm.nih.gov/pubmed/26918349
http://dx.doi.org/10.18632/oncotarget.7648

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