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AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin

AMP-activated protein kinase (AMPK) is an important energy sensor that may inhibit cell proliferation or promote cell survival during stresses. Besides cyclooxygenase, AMPK is another target of the nonsteroid anti-inflammatory agent aspirin. Preclinical and clinical investigations demonstrate that a...

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Detalles Bibliográficos
Autores principales:	Gao, Mei, Kong, Qingbin, Hua, Hui, Yin, Yancun, Wang, Jiao, Luo, Ting, Jiang, Yangfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941319/ https://www.ncbi.nlm.nih.gov/pubmed/26918349 http://dx.doi.org/10.18632/oncotarget.7648

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