KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms

Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. Our results demonstrated that KU-0060648 was anti-proliferative and pro-apoptotic in established (HepG2, Huh-7 and KYN-2 lines) and primary human HCC cells, but was non-cytotoxic to non-cancerous H...

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Detalles Bibliográficos
Autores principales: Chen, Min-Bin, Zhou, Zhen-Tao, Yang, Lan, Wei, Mu-Xin, Tang, Min, Ruan, Ting-Yan, Xu, Jun-Ying, Zhou, Xiao-zhong, Chen, Gang, Lu, Pei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941370/
https://www.ncbi.nlm.nih.gov/pubmed/26933997
http://dx.doi.org/10.18632/oncotarget.7742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941370/
https://www.ncbi.nlm.nih.gov/pubmed/26933997
http://dx.doi.org/10.18632/oncotarget.7742

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