Cargando…

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms

Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. Our results demonstrated that KU-0060648 was anti-proliferative and pro-apoptotic in established (HepG2, Huh-7 and KYN-2 lines) and primary human HCC cells, but was non-cytotoxic to non-cancerous H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Min-Bin, Zhou, Zhen-Tao, Yang, Lan, Wei, Mu-Xin, Tang, Min, Ruan, Ting-Yan, Xu, Jun-Ying, Zhou, Xiao-zhong, Chen, Gang, Lu, Pei-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941370/ https://www.ncbi.nlm.nih.gov/pubmed/26933997 http://dx.doi.org/10.18632/oncotarget.7742

Ejemplares similares

Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling
por: Lan, Tian, et al.
Publicado: (2016)

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
por: Beskow, C, et al.
Publicado: (2009)

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
por: Reynolds, Pamela, et al.
Publicado: (2012)

Transcriptome dataset of HEK293T cells depleted of one of the subunits of the DNA-PK complex: Ku70, Ku80 or DNA-PKcs
por: Anisenko, Andrey, et al.
Publicado: (2021)

DNA-PKcs participated in hypoxic pulmonary hypertension
por: Liu, Ying-ying, et al.
Publicado: (2022)

Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells
por: Cheng, Long, et al.
Publicado: (2017)

Unraveling the roles of WRN and DNA-PKcs at telomeres
por: Beattie, Tara L., et al.
Publicado: (2010)

Lost in the bloom: DNA-PKcs in green plants
por: Kumar, Koppolu Raja Rajesh
Publicado: (2023)

Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1
por: Yamauchi, Motohiro, et al.
Publicado: (2017)

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
por: Yue, Xiaoqiao, et al.
Publicado: (2020)

DNA structure-specific priming of ATR activation by DNA-PKcs
por: Vidal-Eychenié, Sophie, et al.
Publicado: (2013)

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells
por: Zhen, Yun-fang, et al.
Publicado: (2016)

Targeting DNA-PKcs and telomerase in brain tumour cells
por: Gurung, Resham Lal, et al.
Publicado: (2014)

DNA-PKcs: A Targetable Protumorigenic Protein Kinase
por: Dylgjeri, Emanuela, et al.
Publicado: (2022)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity
por: Yang, Haitang, et al.
Publicado: (2020)

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
por: Liang, Shikang, et al.
Publicado: (2022)

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
por: Espejel, Silvia, et al.
Publicado: (2004)

DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy
por: Geng, Wei, et al.
Publicado: (2019)

Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq
por: Song, Zhiquan, et al.
Publicado: (2019)

Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer
por: Wang, Fu-Rong, et al.
Publicado: (2017)

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response
por: Guo, Zongpei, et al.
Publicado: (2020)

Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs
por: Bosch-Guiteras, Núria, et al.
Publicado: (2021)

Structural analysis of the basal state of the Artemis:DNA-PKcs complex
por: Watanabe, Go, et al.
Publicado: (2022)

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer
por: Wang, You-hong, et al.
Publicado: (2021)

PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
por: Li, Bing, et al.
Publicado: (2013)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
por: Hammel, Michal, et al.
Publicado: (2016)

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity
por: Gupta, Shikha, et al.
Publicado: (2005)

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs
por: Dregalla, Ryan C., et al.
Publicado: (2010)

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
por: Kusumoto-Matsuo, Rika, et al.
Publicado: (2010)

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray
por: Lafont, Florian, et al.
Publicado: (2018)

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes
por: Kim Wiese, Ara, et al.
Publicado: (2017)

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex
por: Chang, Howard H.Y., et al.
Publicado: (2016)

Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells
por: Zhang, Jing, et al.
Publicado: (2022)

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
por: Zhang, Shichuan, et al.
Publicado: (2011)

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle
por: Davis, Anthony J., et al.
Publicado: (2014)

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2015)

DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism
por: Chen, Wei‐Min, et al.
Publicado: (2023)

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
por: Han, Yang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e6o8tk555ovjgeh3jee648bdrc