N52 monodeamidated Bcl–x(L) shows impaired oncogenic properties in vivo and in vitro

Bcl-x(L) is a member of the Bcl-2 family, playing a critical role in the survival of tumor cells. Here, we show that Bcl-x(L) oncogenic function can be uncoupled from its anti-apoptotic activity when it is regulated by the post-translational deamidation of its Asn52. Bcl-x(L) activity can be regulat...

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Detalles Bibliográficos
Autores principales: Beaumatin, Florian, Dhaybi, Mohamad El, Lasserre, Jean-Paul, Salin, Bénédicte, Moyer, Mary Pat, Verdier, Mireille, Manon, Stéphen, Priault, Muriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941376/
https://www.ncbi.nlm.nih.gov/pubmed/26958941
http://dx.doi.org/10.18632/oncotarget.7938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941376/
https://www.ncbi.nlm.nih.gov/pubmed/26958941
http://dx.doi.org/10.18632/oncotarget.7938

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