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N52 monodeamidated Bcl–x(L) shows impaired oncogenic properties in vivo and in vitro
Bcl-x(L) is a member of the Bcl-2 family, playing a critical role in the survival of tumor cells. Here, we show that Bcl-x(L) oncogenic function can be uncoupled from its anti-apoptotic activity when it is regulated by the post-translational deamidation of its Asn52. Bcl-x(L) activity can be regulat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941376/ https://www.ncbi.nlm.nih.gov/pubmed/26958941 http://dx.doi.org/10.18632/oncotarget.7938 |