Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene

Bacterial lipoproteins are extracellular proteins tethered to cell membranes by covalently attached lipids. Deleting the lipoprotein signal peptidase (lsp) gene in Streptomyces coelicolor results in growth and developmental defects that cannot be restored by reintroducing lsp. This led us to hypothe...

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Detalles Bibliográficos
Autores principales: Munnoch, John T., Widdick, David A., Chandra, Govind, Sutcliffe, Iain C., Palmer, Tracy, Hutchings, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941574/
https://www.ncbi.nlm.nih.gov/pubmed/27404047
http://dx.doi.org/10.1038/srep29495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941574/
https://www.ncbi.nlm.nih.gov/pubmed/27404047
http://dx.doi.org/10.1038/srep29495

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