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Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9
CRISPR/Cas9 genome editing has been proposed as a therapeutic treatment for HIV-1 infection. CRISPR/Cas9 induced double strand breaks (DSBs) targeted to the integrated viral genome have been shown to decrease production of progeny virus. Unfortunately HIV-1 evolves rapidly and may readily produce CR...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941621/ https://www.ncbi.nlm.nih.gov/pubmed/27404981 http://dx.doi.org/10.1038/srep29530 |