Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib

Overexpression of ABCB1 (also called P-glycoprotein) confers resistance to multiple anticancer drugs, including tyrosine kinase inhibitors (TKIs). Several ABCB1 single nucleotide polymorphisms affect the transporter activity. The most common ABCB1 variants are 1236C > T, 2677G > T, 3435C > ...

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Detalles Bibliográficos
Autores principales: Dessilly, Géraldine, Panin, Nadtha, Elens, Laure, Haufroid, Vincent, Demoulin, Jean-Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941718/
https://www.ncbi.nlm.nih.gov/pubmed/27405085
http://dx.doi.org/10.1038/srep29559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941718/
https://www.ncbi.nlm.nih.gov/pubmed/27405085
http://dx.doi.org/10.1038/srep29559

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