Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability

Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the...

Descripción completa

Detalles Bibliográficos
Autores principales: Lori, Laura, Pasquo, Alessandra, Lori, Clorinda, Petrosino, Maria, Chiaraluce, Roberta, Tallant, Cynthia, Knapp, Stefan, Consalvi, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942050/
https://www.ncbi.nlm.nih.gov/pubmed/27403962
http://dx.doi.org/10.1371/journal.pone.0159180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942050/
https://www.ncbi.nlm.nih.gov/pubmed/27403962
http://dx.doi.org/10.1371/journal.pone.0159180

Ejemplares similares