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Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942050/ https://www.ncbi.nlm.nih.gov/pubmed/27403962 http://dx.doi.org/10.1371/journal.pone.0159180 |