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AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials

In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The applicati...

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Detalles Bibliográficos
Autores principales: Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942070/
https://www.ncbi.nlm.nih.gov/pubmed/27403961
http://dx.doi.org/10.1371/journal.pone.0159026